• Antibacterial use by birth year and birth season in children 0-2 years in Norway 

      Beckstrøm, Sanna; Svendsen, Kristian; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
      Introduction: Consumption of antibacterials in children follows seasonal cycles, and time to first treatment depends on birth season. The aim of this study was to describe dispensing rate, one-year periodic prevalence, and age at first prescription in children aged 0-2 years in Norway. Methods: We used data from the Norwegian prescription database and included all dispensed prescriptions on systemic ...
    • Assessing Potentially Inappropriate Medications in Nursing Home Residents by NORGEP-NH Criteria 

      Halvorsen, Kjell H.; Kucukcelik, Sinan; Garcia, Beate Hennie; Svendsen, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-05)
      <p><i>Background</i>: Nursing home residents often have several conditions that necessitate the use of multiple medicines. This study investigates the prevalence of potentially inappropriate medications (PIMs) and its associations with sex, age, number of medicines, and study location (rural/urban).</p> <p><i>Methods:</i> A cross-sectional study of long-term care residents from six nursing ...
    • Association of area-level education with the regional growth trajectories of rates of antibacterial dispensing to patients under 3 years in Norway: a longitudinal retrospective study 

      Svalestuen, Sigbjørn; Svendsen, Kristian; Eggen, Anne Elise; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)
      Objective To examine the association between area-level education and the local growth trajectories in antibacterial dispensing rates in Norwegian municipalities among children under 3 years old.<p> <p>Design Retrospective, longitudinal study using individual primary care prescription data from the Norwegian Prescription Database for the period 2006–2016. Data were collected on the date of ...
    • Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates 

      Raffelsberger, Niclas Peter; Buczek, Dorota Julia; Svendsen, Kristian; Småbrekke, Lars; Pöntinen, Anna Kaarina; Löhr, Iren Høyland; Andreassen, Lotte Leonore Eivindsdatter; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn Ståle; Gravningen, Kirsten; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-12)
      The global prevalence of infections caused by extended-spectrum βlactamase-producing Enterobacterales (ESBL-E) is increasing, and for Escherichia coli, observations indicate that this is partly driven by community-onset cases. The ESBL-E population structure in the community is scarcely described, and data on risk factors for carriage are conflicting. Here, we report the prevalence and population ...
    • Completeness of medication information in admission notes from emergency departments 

      Zahl-Holmstad, Birgitte; Garcia, Beate Hennie; Svendsen, Kristian; Johnsgård, Tine; Vesela, Renata; Ofstad, Eirik Hugaas; Risør, Torsten; Lehnbom, Elin Christina; Wisløff, Torbjørn; Chan, Macty; Elenjord, Renate (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-16)
      Background - Medication lists prepared in the emergency department (ED) form the basis for diagnosing and treating patients during hospitalization. Since incomplete medication information may lead to patient harm, it is crucial to obtain a correct and complete medication list at hospital admission. In this cross-sectional retrospective study we wanted to explore medication information completeness ...
    • Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study 

      Høgli, June Utnes; Garcia, Beate Hennie; Svendsen, Kristian; Skogen, Vegard; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-15)
      <i>Background</i> - Norwegian guideline recommendations on first-line empirical antibiotic prescribing in hospitalised patients with community-acquired pneumonia (CAP) are penicillin G/V in monotherapy, or penicillin G in combination with gentamicin (or cefotaxime) in severely ill patients. The aim of this study was to explore how different empirical antibiotic treatments impact on length of hospital ...
    • Gastrointestinal carriage of Klebsiella pneumoniae in a general adult population: a cross-sectional study of risk factors and bacterial genomic diversity 

      Raffelsberger, Niclas Peter; Hetland, Marit Andrea Klokkhammer; Svendsen, Kristian; Småbrekke, Lars; Löhr, Iren Høyland; Andreassen, Lotte; Brisse, Sylvain; Holt, Kathryn E.; Sundsfjord, Arnfinn; Samuelsen, Ørjan; Gravningen, Kirsten Midttun (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-28)
      Antibiotic resistant <i>Klebsiella pneumoniae</i> is a leading public health threat and gastrointestinal carriage is an established risk factor for subsequent infections during hospitalization. Our study contributes new knowledge of risk factors for gastrointestinal carriage and the genomic population structure of <i>K. pneumoniae</i> colonizing humans in a representative sample of a general population ...
    • The impact of hospitalisation to geriatric wards on the use of medications and potentially inappropriate medications - A health register study 

      Johansen, Jeanette Schultz; Halvorsen, Kjell H.; Svendsen, Kristian; Havnes, Kjerstin; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-01)
      <i>Background</i> - The use of potentially inappropriate medications (PIMs) are associated with negative health effects for older adults. The purpose of this study was to apply national register data to investigate the impact of hospitalisation to geriatric wards in Norway on the use of medications and PIMs, and to compare two explicit PIM identification tools.<p><p> <i>Methods</i> - We included ...
    • Integrating the clinical pharmacist into the emergency department interdisciplinary team: A study protocol for a multicentre trial applying a non-randomised stepped-wedge study design 

      Vesela, Renata; Elenjord, Renate; Lehnbom, Elin; Ofstad, Eirik Hugaas; Johnsgård, Tine; Zahl-Holmstad, Birgitte; Risør, Torsten; Wisløff, Torbjørn; Røslie, Lars; Filseth, Ole Magnus; Valle, Per Christian; Svendsen, Kristian; Frøyshov, Hanne Mathilde; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      Introduction: The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact ...
    • Integrating the clinical pharmacist into the emergency department interdisciplinary team: a study protocol for a multicentre trial applying a non-randomised stepped-wedge study design 

      Vesala, Renata; Elenjord, Renate; Lehnbom, Elin; Ofstad, Eirik Hugaas; Johnsgård, Tine; Zahl-Holmstad, Birgitte; Risør, Torstein; Wisløff, Torbjørn; Røslie, Lars; Filseth, Ole Magnus; Valle, Per Christian; Svendsen, Kristian; Frøyshov, Hanne Mathilde; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      Introduction - The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact of ...
    • Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trial 

      Johansen, Jeanette Schultz; Halvorsen, Kjell H.; Svendsen, Kristian; Havnes, Kjerstin; Robinson, Eirin Guldsten; Wetting, Hilde Ljones; Haustreis, Stine; Småbrekke, Lars; Kamycheva, Elena; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-26)
      <b><p>Background</b> Suboptimal medication use contributes to a substantial proportion of hospitalizations and emergency department visits in older adults. We designed a clinical pharmacist intervention to optimize medication therapy in older hospitalized patients. Based on the integrated medicine management (IMM) model, the 5-step IMMENSE intervention comprise medication reconciliation, medication ...
    • Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (The IMMENSE study) – a randomized controlled trial 

      Johansen, Jeanette Schultz; Halvorsen, Kjell H.; Svendsen, Kristian; Havnes, Kjerstin; Robinson, Eirin Guldsten; Ljones Wetting, Hilde; Haustreis, Stine; Småbrekke, Lars; Kamycheva, Elena; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-26)
      Background - Suboptimal medication use contributes to a substantial proportion of hospitalizations and emergency department visits in older adults. We designed a clinical pharmacist intervention to optimize medication therapy in older hospitalized patients. Based on the integrated medicine management (IMM) model, the 5-step IMMENSE intervention comprise medication reconciliation, medication review, ...
    • Intervention fidelity and process outcomes of the IMMENSE study, a pharmacist-led interdisciplinary intervention to improve medication safety in older hospitalized patients 

      Johansen, Jeanette Schultz; Halvorsen, Kjell H.; Havnes, Kjerstin; Wetting, Hilde Ljones; Svendsen, Kristian; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-21)
      What is known and Objective - The majority of hospitalized older patients experience medication-related problems (MRPs), and there is a call for interventions to solve MRPs and improve clinical outcomes like medical visits. The IMMENSE study is a randomized controlled trial investigating the impact of a pharmacist-led interdisciplinary intervention on emergency medical visits. Its multistep intervention ...
    • An introduction to network analysis for studies of medication use 

      Askar, Mohsen Gamal Saad; Nozal Cañadas, Rafael; Svendsen, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-29)
      Background - Network Analysis (NA) is a method that has been used in various disciplines such as Social sciences and Ecology for decades. So far, NA has not been used extensively in studies of medication use. Only a handful of papers have used NA in Drug Prescription Networks (DPN). We provide an introduction to NA terminology alongside a guide to creating and extracting results from the medication ...
    • Is anticholinergic and sedative drug burden associated with postdischarge institutionalization in community-dwelling older patients acutely admitted to hospital? A Norwegian registry-based study 

      Havnes, Kjerstin; Svendsen, Kristian; Johansen, Jeanette Schultz; Granås, Anne Gerd; Garcia, Beate Hennie; Halvorsen, Kjell H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-30)
      Purpose: Investigate the association between anticholinergic (AC) and sedative (SED)drug burden before hospitalization and postdischarge institutionalization (PDI) incommunity-dwelling older patients acutely admitted to hospital.<p><p>Methods: A cross-sectional study using data from the Norwegian Patient Registryand the Norwegian Prescription Database. We studied acutely hospitalizedcommunity-dwelling ...
    • Patient perceptions and experiences with medication-related activities in the emergency department: a qualitative study 

      Zahl-Holmstad, Birgitte; Garcia, Beate Hennie; Johnsgård, Tine; Ofstad, Eirik Hugaas; Lehnbom, Elin; Svendsen, Kristian; Risør, Torsten; Vesela, Renata; Elenjord, Renate (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)
      Background - Emergency department (ED) pharmacists reduce medication errors and improve quality of medication use. Patient perceptions and experiences with ED pharmacists have not been studied. The aim of this study was to explore patients’ perceptions of and experiences with medication-related activities in the ED, with and without an ED pharmacist present.<p> <p>Methods - We conducted 24 ...
    • Risk factors, immune response and whole‐genome sequencing of SARS‐CoV‐2 in a cruise ship outbreak in Norway 

      Gravningen, Kirsten Midttun; Henriksen, Stian; Hungnes, Olav; Svendsen, Kristian; Macdonald, Emily Ann; Schirmer, Henrik; Stene-Johansen, Kathrine; Simonsen, Gunnar Skov; Kacelnik, Oliver; Elstrøm, Petter; Bragstad, Karoline; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-18)
      Objective: To improve understanding of SARS-CoV-2-transmission and prevention measures on cruise ships, we investigated a Norwegian cruise ship outbreak from July to August 2020 using a multidisciplinary approach after a rapid outbreak response launched by local and national health authorities. Methods: We conducted a cross-sectional study among crew members using epidemiologic data and results ...
    • Self-reported medication information needs among medication users in a general population aged 40 years and above – the Tromsø study 

      Walquist, Mari Johannessen; Svendsen, Kristian; Garcia, Beate Hennie; Bergmo, Trine Strand; Eggen, Anne Elise; Halvorsen, Kjell H.; Småbrekke, Lars; Ringberg, Unni; Lehnbom, Elin; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-25)
      Purpose: To determine the prevalence and associated factors of self-reported medication information needs among medication users in a general population aged 40 years and above – The Tromsø Study.<p> <p>Methods: Cross-sectional study of medication users (n=10,231) among participants in the Tromsø Study, a descriptive analysis of questionnaire data and multivariable logistic regression (n=9,194). Results: ...
    • Self-reported medication use among coronary heart disease patients showed high validity compared with dispensing data 

      Pedersen, Elisabeth; Truong, Kieu Nhi Lise; Garcia, Beate Hennie; Halvorsen, Kjell H.; Svendsen, Kristian; Eggen, Anne Elise; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-24)
      <i>Objective</i> - To validate self-reported use of medications for secondary prevention of coronary heart disease (CHD) in a population-based health study by comparing self-report with pharmacy dispensing data, and explore different methods for defining medication use in prescription databases.<br><br> <i>Study design and setting</i> - Self-reported medication use among participants with CHD ...
    • Social network analysis of Staphylococcus aureus carriage in a general youth population 

      Stensen, Dina Benedicte Berg; Cañadas, Rafael A. Nozal; Småbrekke, Lars; Olsen, Karina; Nielsen, Christopher Sivert; Svendsen, Kristian; Hanssen, Anne Merethe; Ericson, Johanna U; Simonsen, Gunnar Skov; Bongo, Lars Ailo; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-31)
      Objectives Staphylococcus aureus carriage increases infection risk. We used social network analysis to evaluate whether contacts have the same S. aureus genotype indicating direct transmission, or whether contagiousness is an indirect effect of contacts sharing the same lifestyle or characteristics. Methods The Fit Futures 1 study collected data on social contact among 1038 high school students. ...